Manchester City triumphed in the derby at United, Chelsea and Liverpool both dropped points and two managers lost their jobs.
Roma’s poor form under Jose Mourinho continued as they were beaten 3-2 at Venezia on Sunday.
Jurgen Klopp was furious with the officials after West Ham punished three mistakes from Liverpool goalkeeper Alisson Becker and ended the Reds' 25-match unbeaten run with a 3-2 victory on Sunday.
Antonio Conte has promised to give Dele Alli the chance to resurrect his Tottenham Hotspur career.
Thomas Tuchel admitted Chelsea had only themselves to blame as the Premier League leaders were held to a surprise 1-1 draw by struggling Burnley on Saturday.
Pep Guardiola praised his team for silencing Old Trafford after his Manchester City side eased to a comfortable 2-0 derby win over Manchester United.
Manchester United manager Ole Gunnar Solskjaer said he does not feel as though he is on borrowed time despite a chastening 2-0 defeat by Manchester City on Saturday.
Matej Vydra pounced to stun sloppy Chelsea and scramble Burnley a 1-1 Premier League draw at Stamford Bridge.
Manchester United suffered another home humiliation as Manchester City cruised to a 2-0 win at Old Trafford on Saturday to raise further questions over the future of Ole Gunnar Solskjaer.
Liverpool are on the verge of surpassing the record of the club’s great side of the 1980s but manager Jurgen Klopp insists his players do not want to be compared as they are creating their own history.