Arsenal's bid to finish in the Premier League's top four suffered a significant setback as Crystal Palace swept to an impressive 3-0 win on Monday.
Manchester City and Liverpool made sure their clash next Sunday may prove to be a Premier League title decider on a weekend that showed the top two are a class above the rest.
Liverpool's quest for a quadruple and Manchester City's bid to match Manchester United's historic treble of 1999 are on a collision course over the next two weeks.
Tottenham powered into fourth place in the Premier League with a 5-1 rout of Newcastle, while West Ham's 2-1 victory pushed Everton deeper into relegation trouble on Sunday.
Pep Guardiola said Manchester City have already had an incredible season by putting themselves into position to fight for three trophies in the closing months of the campaign.
Liverpool manager Jurgen Klopp said winning the Premier League is his priority after the Reds went top of the table for the first time this year thanks to a 2-0 win over Watford.
Manchester United dropped more valuable points as they drew 1-1 at home to Leicester on Saturday, slipping further off the pace in the battle to secure Champions League football for next season.
Liverpool defender Trent Alexander-Arnold missed England's friendlies with a hamstring injury but manager Jurgen Klopp has revealed that he should be fit for the clashes against Manchester City and Benfica.
Ralf Rangnick said he finds it hard to understand why Manchester United defender Harry Maguire was booed by England fans before this week's friendly against Ivory Coast.
Bruno Fernandes extended his contract at Manchester United till 2026 on Friday in a deal expected to make the Portuguese midfielder one of the club's highest earners.