A howler by David De Gea condemned Manchester United to a 1-0 defeat against West Ham at the London Stadium leaving their top-four hopes at risk.
Erling Haaland set a new Premier League goal record to help Manchester City defeat West Ham United 3-0 to move back to the top of the table on Wednesday.
Liverpool kept their top four hopes alive after they came back to beat West Ham United 2-1 in their Premier League clash at the London Stadium on Wednesday evening.
Arsenal manager Mikel Arteta is confident his side will return to winning ways against Southampton after back to back draws against Liverpool and West Ham United in the Premier League.
Arsenal extended their lead at the top of the Premier League table following their 3-1 win over West Ham United, while Liverpool secured a comfortable 3-1 win over Aston Villa in a hugely entertaining game at Villa Park.
Watch as Marcus Rashford bagged his 100th goal for Manchester United to inspire them to a hard-fought 1-0 win over West Ham United at Old Trafford on Sunday.
Watch as Kai Havertz and Ben Chilwell inspire Chelsea to fight back and secure a 2-1 victory over London rivals West Ham United at Stamford Bridge on Saturday afternoon.
Erling Haaland hit a second successive hat-trick as Manchester City crushed Nottingham Forest 6-0, while leaders Arsenal extended their perfect start to the Premier League season with a 2-1 win against Aston Villa on Wednesday.
Manchester City staged a thrilling fightback as the Premier League champions rescued a 3-3 draw against Newcastle, while Edouard Mendy's embarrassing blunder condemned Chelsea to a 3-0 defeat at Leeds on Sunday.
Erling Haaland scored twice on his Premier League debut as Manchester City opened their defence of the title with a 2-0 win at West Ham on Sunday.