Chelsea showed they can thrive without Romelu Lukaku as Kai Havertz scored after replacing the axed Belgium striker for the 2-0 Champions League last-16, first-leg win against Lille on Tuesday.
If winning La Liga caused Atletico Madrid to soften their edge or lose their identity, a Champions League tie against Manchester United could be a chance for them to get it back.
Sebastien Haller will be bidding to continue his remarkable scoring record in this season's Champions League when his Ajax side face Benfica in the first leg of their last-16 tie on Wednesday.
Liverpool manager Jurgen Klopp insists their 2-0 win over Inter Milan in their Champions League last-16 tie does not mean they can put their feet up for the home leg.
Liverpool put one foot in the Champions League quarter-finals with a 2-0 win at Inter Milan, while Kingsley Coman spared his side's blushes with a late equaliser as Bayern Munich laboured to a 1-1 draw away to Red Bull Salzburg on Wednesday.
Neymar could play his first game for Paris Saint-Germain since November when they face Real Madrid in the first leg of their Champions League last-16 tie on Tuesday.
Liverpool defender Virgil Van Dijk is back to his best with perfect timing for the remainder of the season, according to manager Jurgen Klopp.
Edin Dzeko will take to the San Siro pitch with old friend Mohamed Salah when Inter Milan take on Liverpool in the Champions League last 16 on Wednesday, a reminder of the havoc the pair used to cause together at Roma.
Ralf Rangnick has warned his Manchester United players they will miss out on a Champions League place if they continue to drop points in the fashion they did at Burnley on Tuesday night.
European champions Chelsea announced Thursday an annual loss of £145.6 million ($196.7 million, 173.5 million euros) for the year to June 30 2021 despite their Champions League triumph.