Manchester City maintained a one-point Premier League lead over Liverpool with four games to go after seeing off Leeds 4-0 on Saturday as Norwich were relegated after a 2-0 loss at Aston Villa.
Gabriel Jesus scored four goals as Manchester City thrashed Watford 5-1 to open up a four-point lead in the Premier League title race, while Arsenal beat Manchester United 3-1 to take control of the race for fourth as Tottenham Hotspur were held to a 0-0 draw by Brentford.
In a potential pivotal day at the top end of the Premier League, Manchester City had their unbeaten run halted by Tottenham Hotspur in a dramatic five-goal thriller while Liverpool overcame a scare to beat Norwich and Chelsea snatched a late win at Crystal Palace on Saturday.
Tottenham Hotspur face a daunting trip to Manchester City this weekend, desperate to arrest a losing streak that threatens to derail their season as Manchester United brace themselves for a hostile reception at Leeds.
Manchester United's top four bid suffered another blow as Southampton hit back to earn a 1-1 draw, while Manchester City thrashed Norwich 4-0 with Raheem Sterling bagging a hattrick.
Philippe Coutinho made a dream debut for Aston Villa as the Brazil star's late equaliser capped a thrilling fightback from two goals down against Manchester United in Saturday's 2-2 draw.
Cristiano Ronaldo extended Ralf Rangnick's unbeaten start as Manchester United interim manager as the Portugal striker's penalty clinched a 1-0 victory at struggling Norwich on Saturday.
Manchester City triumphed in the derby at United, Chelsea and Liverpool both dropped points and two managers lost their jobs.
Cristiano Ronaldo bagged a double as Manchester United thrashed Newcastle United 4-1 at Old Trafford while Manchester City edged Leicester City 1-0 courtesy of a strike from Bernardo Silva.
Liverpool were 3-0 winners away to promoted Norwich thanks to goals from Diogo Jota, Roberto Firmino and Mohamed Salah on the opening day of the season.