A penalty by Jonathan David saw Lille hand holders Real Madrid their first Champions League defeat since May 2023 following the French side's 1-0 win at the Pierre-Mauroy Stadium.
A late stunner from Jhon Duran saw Aston Villa secure a shock 1-0 victory over Bayern Munich in the Champions League at Villa Park.
Arne Slot secured his first home Champions League victory following Liverpool's 2-0 win over Bologna at Anfield on Wednesday evening.
Robert Lewandowski netted a brace as Barcelona claimed a dominant 5-0 victory over Young Boys in the Champions League.
Arsenal secured their first win in the new Champions League format following their 2-0 victory over Paris Saint-Germain at Emirates Stadium in London.
Phil Foden played a starring role as Manchester City claimed a comfortable 4-0 victory over Slovan Bratislava in the Champions League.
Manchester City were forced to share the spoils with Inter Milan after playing out to a goalless draw at the Etihad Stadium on Wednesday evening.
Liverpool came from behind to defeat AC Milan 3-1 in their Champions League encounter played at the San Siro in Milan.
Endrick became Real Madrid's youngest Champions League goalscorer as Los Blancos secured a 3-1 victory over Stuttgart at the Santiago Bernabeu in Madrid.
Harry Kane scored four goals to become England's top scorer in the Champions League following Bayern Munich's 9-2 thrashing of Dinamo Zagreb at the Allianz Arena in Munich.