Ishant Sharma took two wickets as the Proteas crawled to tea on 230-7 on day four at Centurion.
Mohammed Shami claimed three key wickets to reduce the Proteas to 173-5 at lunch on day four.
Morne Morkel has ruled out a draw at Centurion and says a lead of 250 might be enough for the Proteas.
The Proteas were 118 runs ahead and still had eight second-innings wickets in hand at stumps on day three at Centurion.
Virat Kohli scored 141 not out to reduce the first-innings deficit to 48 runs at lunch on day three at Centurion.
Your essential guide to the second Test between South Africa and India at SuperSport Park in Centurion.
Faf du Plessis says Chris Morris is not consistent enough to be a third seamer in the Proteas Test team, but fits into a four-seamer attack.
The Proteas’ top-order batsmen must follow AB de Villiers’s lead and take the fight to the India bowlers at Centurion.
The Proteas showed character and class in recording an emphatic first Test victory at Newlands.
The Proteas look set to reap the benefits of a four-prong seam attack in the short-and long-term.